Education and Experience

1958-1961 Brandeis University, Waltham, MA.
1961-1965 University of Miami, School of Medicine, Miami, FL.
1965-1966 Internship (medicine), Jackson Memorial Hospital, Miami, FL.
1966-1969 Residency (neurology), Stanford University Hospital, Palo Alto, CA.
1969-1971 Head, Neurology Branch, Navy Neuropsychiatric Research Unit, San Diego, CA. 1972-1979 Associate Staff - Neurology* & Microbiology, Scripps
through 1982* Clinic and Research Foundation, La Jolla, CA.
1979-Present Director, Center for Neurologic Study, San Diego, CA.
1982-Present Senior Medical Staff, Scripps Memorial Hospital, La Jolla, CA.

Awards

Henry Newman Award - 1968 (San Francisco Neurologic Society)
Skaggs Clinical Scholar - 1999-2001 (Scripps Clinic and Research Foundation)

Professional Societies

• Associate, American Academy of Neurology
• American Association for the Advancement of Science
• San Diego Neurologic Society

Selected Publications

Hoffmann, W., Smith, R.A. (1970) Hypokalemic Periodic Paralysis. Brain 93: 44.

Smith, R.A., Goode, R. (1970) Sialorrhea. New England Journal of Medicine 293: 917.

Zir, L.M., Smith, R.A., Parker, D.C. (1970) Human Growth Release in Sleep: Effect of Daytime Exercises. Journal of Clinical Endocrinology and Metabolism 32: 622.

Smith, R.A., Johnson, L., Rothfeld, R., Zir, L.M., Tharp, B. (1972) Sleep and Cardiac Arrhythmias. Archives of Internal Medicine 130: 751.

Zir, L.M., Parker, D., Smith, R.A., Rossman, L. (1972) The Relationship of Human Growth Hormone and Plasma Tyrosine During Sleep. Journal of Clinical Endocrinology and Metabolism 31: 1.

Smith, R.A., Norris, F. (1975) The Care of Patients with ALS. Journal of the American Medical Association 234: 717.

Meinke, W., Smith, R.A., Lancaster, W.D., Goldstein, D.A., Tourtellote, W.W. (1977) In Vitro Labelled DNA for Detection of Viral Genomes in Multiple Sclerosis: 1. Papoviruses. Neurology 27: 736.

Meinke, W., Goldstein, D.A., Lancaster, W.D., Smith, R.A. (1979) Simian Virus 40-Related DNA sequences in a Human Brain Tumor. Neurology 29: 1590.

Smith, R.A., Dawson, A., Foroozan, P. (1980) Pharmacologic and Surgical Modalities. The Diagnosis and Treatment of Amyotrophic Lateral Sclerosis, Donald W. Mulder, MD (Ed.), Houghton Mifflin, Professional Publishers, Boston.

Tracy, S., Smith, R.A. (1981) A Comparison of the Genomes of Polioviruses by cDNA: RNA Hybridization. Journal of General Virology 55:193.

Kohne, D.E., Gibbs, C.J., White, L., Tracy, S.M., Meinke, W., Smith, R.A. (1981) Virus Detection by Nucleic Acid Hybridization: Examination of Normal and ALS Tissues for the Presence of Poliovirus. Journal of General Virology 56:223.

Salazar, A.M., Gibbs, C.J., Gajdusek, D.C., Smith, R.A. (1984) Clinical Usage of Interferons: Central Nervous System Disorders. Interferons and Their Applications, Handbook of Experimental Pharmacology, P.E. Came & W.A. Carter (Editors), Vol. 71, 23:471.

Smith, R.A., Norris, F., Palmer, D., Bernhardt, L., Wills, R.J. (1985) Distribution of Alpha Interferon in Serum and Cerebrospinal Fluid After Systemic Administration. Journal of Clinical Pharmacology and Therapeutics 37:85.

Norris, F.H., Smith, R.A., Denys, E.H. (1985) Motor Neuron Disease: Towards Better Care, British Medical Journal 291:259.

Brahic, M., Smith, R.A., Gibbs, C.J., Garruto, R.M., Tourtellotte, W.W., Cash, E. (1985) Detection of Picornavirus Sequences in Nervous Tissue of Amyotrophic Lateral Sclerosis and Control Patients. Annals of Neurology 18:337.

Panitch, H.S., Gomez, J., Norris, F.H., Cantell, K., Smith, R.A. (1986) Remission of Subacute Sclerosing Panencephalitis in Patients Treated with Intraventricular Interferon. Neurology 36: 562-566.

Smith, R.A., Abramsky, O., Steiner, I., Panitch, H., Cantell, K. (1986) The Experimental Treatment of Subacute Sclerosing Panencephalitis with Interferon. The Biology of the Interferon System 1985, W.E. Stewart & H. Schellekens (Editors),Elsevier Science Publishers B.V., Amsterdam, The Netherlands.

Gresham, L.S., Molgaard, C.A., Golbeck, A.L. and Smith, R. (1986) Amyotrophic Lateral Sclerosis and Occupational Heavy Metal Exposure: A Case-Control Study. Neuroepidemiology 5:29-38.

Smith, R.A., Norris, F.H. Antiviral Therapy. (1987) Research, Psychological and Treatment Aspects of ALS, L. Charash, R. Lovelace, et al. (Editors), Elsevier Science Publishers B.V., Amsterdam, The Netherlands, pp 297-304.

Smith, R.A., Norris, F. (1987) Caring for Patients with Amyotrophic Lateral Sclerosis. Psychosocial Aspects of Muscular Dystrophy and Allied Diseases, L. Carash, R. Lovelace, et al. (Editors), p 23.

Smith, R.A. (1987) On Behalf of the Patient. Research, Psychological and Treatment Aspects of ALS, Elsevier Science Publishers B.V., Amsterdam, The Netherlands, pp 319-322.

Smith, R.A., Landel, C.P., Cornelius, C.E. and Revel, M. (1987) Mapping the Action of Interferon on Primate Brain. The Biology of the Interferon System, 1986 - Proceedings of the 1986 TNO-ISIR Congress, K. Cantell & H. Schellekens (Editors), Elsevier Science Publishers, B.V., Amsterdam, the Netherlands, pp 563-566.

Margolis, R.S., Whitten,R., Rauch, C.T., Hassain, H., Smith, R.A. (1988) Characterization of Microtubule Associated Proteins in Amyotrophic Lateral Sclerosis. Amyotrophic Lateral Sclerosis, Research Aspects, T. Tsubake & Y. Yase (Editors), Elsevier Science Publishers, B.V., Amsterdam, The Netherlands, pp 325-332.

Smith, R.A., Norris, F.H. (1988) The Treatment of Amyotrophic Lateral Sclerosis with Interferon. Interferon Treatment of Neurologic Disorders, R.A. Smith (Ed.), Marcel Dekker, New York, pp 265-276.

Wills, R.J., Smith, R.A., (1988) Pharmacokinetics of Interferons. Interferon Treatment of Neurologic Disorders, R.A. Smith (Ed.), Marcel Dekker, New York, pp 103-133.

Smith, R.A., Jacoby, S., Festoff, B., Melmed, S., Frane, J., Sherman, B. (1990) The Influence of Compliance and Other Human Factors On Treatment Trials. Methodological Problems in ALS Trials, F.C. Rose(Ed.), Demos Publications, New York.

Eldon, M.A., Smith, R.A., Leese, P.T., Daigle, A.E., Katy, D.V., Richieri, S.P. (1990) Safety and Tolerability of Single Intravenous Doses of T Cell Modulatory Peptide (TCMP-80) in Healthy Volunteers. Journal of Clinical Pharmacology 30:352-357.

Smith, R.A., Valderhaug, K.L., Wedlund, P.J. (1990) The Excitotoxin Hypothesis: Therapeutic Considerations In Amyotrophic Lateral Sclerosis. ALS. New Advances in Toxicology and Epidemiology, Rose, C., & Norris, F. (Editors), Smith-Gordon Publishers.

Smith, R.A. (1991) Experimental Treatment of Amyotrophic Lateral Sclerosis. Handbook of Amyotrophic Lateral Sclerosis  R.A. Smith (Ed.), Marcel Dekker, New York, pp 317-343.

Smith, R.A., Gillie, E., Licht, L. (1991) Palliative Treatment of Motor Neuron Disease. Handbook of Clinical Neurology, Vol. 15(59): Diseases of the Motor System. J.M.B.V. de Jong (Eds.), Elsevier Science Publishers B.V., Amsterdam, pp 459-473.

Smith, R.A., Melmed, S., Sherman, B., Frane, J., Festoff, B. (1993) Double Blind Experimental Treatment Trial Using Recombinant Human Growth Hormone in Amyotrophic Lateral Sclerosis, Muscle and Nerve 16: 624-633.

Zhang, Y., Britto, M.R., Valderhaug, K.L., Wedlund, P.J., Smith, R.A. (1992) Dextromethorphan: Enhancing its Availability Via Quinidine Mediated Inhibition of Cytochrome P450-2D6. Journal of Clinical Pharmacology & Therapeutics, 51:647-655.

Smith, R.A., Licht, J.M., Manley, P.E., Girten, B., Tuttle, R. (1994) Testing the Limits of Palliative Care. ALS-"From Charcot to the Present and into the Future," San Francisco September 11 & 12 1993, F.C. Rose (Ed.), Smith-Gordon & Company Ltd., London, pp 315-324.

Smith, R.A., Balis, F.M., Ott, K.H., Elsberry, D.D., Sherman, M.R., Saifer, M.G.P. (Suppl. 1994) Pharmacokinetics and Tolerability of Ventricularly Administered Superoxide Dismutase in Monkeys and Preliminary Clinical Observations in Familial ALS. Journal of the Neurological Sciences 129:13-18.

ALS CNTF Treatment Study [ACTS] Study Group, A Double-Blind Placebo-Controlled Clinical Trial of Subcutaneous Recombinant Human Ciliary Neurotrophic Factor (rHCNTF) in Amyotrophic Lateral Sclerosis, (1996). Neurology 46:1244-1249.

D.B. Wilson, R.A. Smith, A. Golding, J.R. Nelson, L. Smith, D.J. Carlo, S.W. Brostoff, D.P. Gold, Results of a Phase I Clinical Trial of a T Cell Receptor Peptide Vaccine in Patients with Multiple Sclerosis. I. Analysis of T Cell Receptor Utilization in CSF Cell Populations. Journal of Neuroimmunology 76. N1-2:15-28.

D.P. Gold, R.A. Smith, A. Golding, J.R. Nelson J. Dively, J. Laxer, S. Richieri, D.J. Carlo, S.W. Brostoff, E. Morgan, D.B. Wilson, (1997). Results of a Phase I Clinical Trial of a T Cell Receptor Vaccine in Patients with Multiple Sclerosis. II. Comparative Analysis of TCR Utilization in CSF T Cell Populations Before and After Vaccination with a TCRVB6 CDR2 Peptide. Journal of Neuroimmunology 76. N1-2:29-38.

S.R. Moore, L.S. Gresham, M.. Bromberg, E.J. Kasarkis, R.A. Smith, (August 1997). A Self Report Measure of Affective Lability. Journal of Neurology, Neurosurgery and Psychiatry 63:89-93.

Cudkowitz, M.E., Brown, R.H., Smith, R.A., (1998). Free Radical Toxicity in Amyotrophic Lateral Sclerosis. Glutathione in the Nervous System, Christopher A. Shaw, Ph.D. (Ed.) Taylor & Francis, pp 343-353.

BDNF Study Group (Phase III) (1999) A Controlled Trial of Recominant Methionyl Human BDNF in ALS. Neurology 52:1427-1433.

Smith, R.A, Licht, J., (1999). Neuromuscular Disease. Current Practice of Medicine, Robert C. Bone, MD (Ed.), Current Medicine, Philadelphia, pp 807-817.

Armon, C., Graves, M.C., Moses, D., Forte, D.K., Darby, S.M., Smith, R.A. Linear Estimates of Disease Progression Predict Survival in Patients with ALS. Muscle and Nerve (in press).

Books

Interferon Treatment of Neurologic Disorders, R.A. Smith (ed.), Marcel Dekker, New York, 1988.
Handbook of Amyotrophic Lateral Sclerosis, R.A. Smith (ed.), Marcel Dekker, New York, 1992.

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