Center for Neurologic Study

About CNS and its Mission

The Center for Neurologic Study, a non profit 501C3 corporation, was founded in 1979 with the intent of helping patients and families who have been affected by incurable neurologic diseases, such as amyotropic lateral schlerosis (ALS). To accomplish this, we focus on experimental treatment and patient/family support and education. Along with others, CNS was instrumental in the development of Interferon as a treatment modality. This is now one of the standard therapies for multiple sclerosis. Furthermore, CNS has been a leader in an area now referred to as Translational Medicine; for example, the Center was the first to test a growth factor as a potential treatment for ALS.

Currently, we are working at the forefront of neurological therapies through collaborations with biotech companies and universities, in an effort to develop cutting-edge treatments for neurologic disorders. Most recently, we have been involved with the development of antisense molecules that could represent a major opportunity to treat heritable diseases of the nervous system, such as familial amyotrophic lateral sclerosis and Huntingtons disease. Recently, this work was recognized by the ALS Association, awarding Dr. Don Cleveland/UCSD, Frank Bennett/Isis Pharmaceuticals, and our director, Dr. Richard Smith with an Essey award (see News).

The seminal discovery of DMQ at CNS resulted in the award of 5 U.S. patents. This drug combination was ultimately formulated by Avanir Pharmaceutical Corporation, leading to a product now known as Nuedexta. In clinical trials, this drug was demonstrated to be highly effective for the treatment of emotional lability that occurs in association with neurological conditions, including ALS and multiple sclerosis. In October 2010, Nuedexta had been approved by the Food and Drug Administration for sale in the United States, and in 2013, it was approved in the European Union. Recently, Nuedexta was tested for its effects on behavior in persons with Alzheimer's disease. The positive results were published in the Journal of the American Medical Association (JAMA). In 2012, the ALS Association awarded CNS a grant to study the effect of Nuedexta on speech and swallowing on patients affected by ALS. The results of this study, conducted at 7 academic centers, in collaboration with the Northeast ALS Consorteum (NEALS) and Massachussetts General Hospital (MGH), was just published in the Journal of Neurotherapeutics. To our knowledge, this placebo-controlled trial is the first to demonstrate the enhancement of function in Amyotrophic Lateral Sclerosis.

Our website is the latest in a long-standing effort to provide patient and family education and support. As early as 1979, CNS sponsored monthly educational programs for patients and their interested family members and friends. While this program has been terminated, individual counseling is available for patients who visit CNS. In special circumstances, CNS will provide online counseling. We hope to provide useful guidance for patients impacted by neurodegenerative disorders.

Our success is due in part to the support we have received from individuals, corporations and foundations. We welcome the opportunity to discuss how your support will advance the treatment of presently incurable diseases such as Amyotrophic Lateral Sclerosis and kindred disorders.

On June 5, 2014, the Essey Award in Los Angeles was presented to Drs. Smith, Cleveland, and Bennett for their work on the development of antisense therapeutics as a potential treatment for Amyothropic Lateral Sclerosis. This award was given by the Golden West Chapter for the ALS Association. The link to the film produced by Patrick McMinn can be accessed here.

This presentation to ALS patients/families, sponsored by the ALS association, was made in connection with the 2011 California ALS summit. Dr. Richard Smith's lecture is titled: "Developing therapeutics for amyotrophic lateral sclerosis"

Interview with Dr. Smith at the California ALS research summit 2011.